Superoxide-mediated activation of uncoupling protein 2 causes pancreatic β cell dysfunction
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منابع مشابه
Superoxide-mediated activation of uncoupling protein 2 causes pancreatic beta cell dysfunction.
Failure to secrete adequate amounts of insulin in response to increasing concentrations of glucose is an important feature of type 2 diabetes. The mechanism for loss of glucose responsiveness is unknown. Uncoupling protein 2 (UCP2), by virtue of its mitochondrial proton leak activity and consequent negative effect on ATP production, impairs glucose-stimulated insulin secretion. Of interest, it ...
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تاریخ انتشار 2003